Moronic best friends get themselves locked inside the Bio-Dome, a science experiment, along with a group of environmental scientists for one year.
Bud Macintosh
Doyle Johnson
Dr. Noah Faulkner
Monique
Jen
William Leaky
T.C. Romulus
Olivia Biggs
Mimi Simkins
Denise
Russell
Doyle's Mother
Trent
Parker
Roach
Dr. Petra von Kant
Tenacious D
Tenacious D
Partier
Drummer
Young Doyle
Young Bud
Guard
Reporter Joachim West
Prof. Bloom
Guy
Singer
Guitarist
Partier
Bio-Dome Technician
Anchor Aries West
Vigilante
Vigilante
Cmdr. Gates, SWAT Team
Assistant
Assistant
Narrator
Axl
Woman in Bandstand
